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This typically resolves with water intake after the recommended fasting period

Dihexa is not an approved drug

While normal cells preserve membrane localization of EAATs, their mislocalization in malignant cells together with up-regulation of xCT lead to aberrant handling of glutamate that induces high levels of glutamate in the extracellular space, as seen in gliomas (192) and in breast cancer, where endocrine therapy-resistant cells promote autophagy and glutamate import via EAAT2 (60, 193)

doi: 10.3389/fnagi.2025.1495769 Received 13 September 2024 Accepted 28 March 2025 Published 09 May 2025 Volume 17 - 2025 Edited by Ramesh Kandimalla, Indian Institute of Chemical Technology (CSIR), India Reviewed by Chunchen Xiang, Capital Medical University, China Bruno piljak, University of Zagreb, Croatia Updates Copyright 2025 Li, Zhang, Yu, Xue and Hu

Peng, M

In recent years, considerable efforts have been made to design and synthesis of novel matrine derivatives with better pharmacokinetics profile and efficacy, suggesting the promising potential of matrine and its derivatives towards clinical translation [232,233,234]