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Reported Effects Synaptogenesis (in-vitro): Increased dendritic-spine formation in cultured hippocampal neurons the origin of the ~10-million BDNF ratio, now low-confidence because the source papers were retracted [4]

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Notably, PGE2 suppresses the activation and activity of T cells by enhancing PD-L1 expression and the polarization of TAMs through cAMP and mitochondrial signals, thereby forming a positive feedback cycle [62, 63]