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These carry out the same functions, but hydroxocobalamin needs to be converted to methylcobalamin and adenosylcobalamin by the body before it can be utilised

For example, clioquinol, a lipophilic iron chelator, is able to penetrate the BBB and reduce metal-induced oxidative stress and neuronal damage, but its use has been limited due to concerns about its serious neurotoxicity, including subacute myelo-optic neuropathy (SMON) (Cherny et al., 2001

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Its dual-action profile makes it particularly relevant for research investigating synergistic peptide interactions and coordinated GH pathway activation

In the present study, Tlr4 -deficient mice exhibited similar levels of both GSDMD-FL and GSDMD-N in the cochlea after noise exposure compared to WT controls (Fig