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The FAD is reduced to FADH 2 by NADPH, after which the oxidized cofactor NADP + remains bound to the enzyme

HCM v Nng

The liver stores B12, and these stores can last a significant time (up to several years for non-deficient individuals), but when they are depleted, it takes consistent input to rebuild and maintain them

IR causes erythrocytes to extravasate to surrounding tissues and heme-iron is released via macrophage-mediated hemolysis in tissues, which is subsequently degraded to ferrous iron and other constituents [42]