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Indeed, sulfasalazine (which inhibits SLC7A11) effectively suppresses the proliferation of glutamine-depleted TNBC in vitro and in vivo 60

The H 2 O 2 molecule closest to the active site oxidises the resting enzyme to Compound 1, and is itself reduced to water

2025a;12:e06150

First, our study was a single-arm study without a control group

Journal of Hazardous Materials, 413 , 125423

M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages