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It is a cofactor for methionine synthase, the enzyme that converts homocysteine to methionine (which is important for healthy nerve myelin)
They are bio-technologically produced
Alarcn-Segovia et al
482 Recent studies have demonstrated alterations in the gut microbiota of patients with diabetic CAN
This mechanism suggests that effective therapies may require intracellular delivery and interruption of cell-to-cell transmission, both of which present substantial delivery challenges (Lasagna-Reeves et al., 2012