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Topical is actually more effective for those specific goals because of direct tissue contact

The famous ~seven orders of magnitude (ten-million-fold) more potent than BDNF figure comes from a single in-vitro spine-counting assay comparing two molecules that signal through entirely different receptors

S.AndrewsA

Clinical pharmacology and therapeutics, 17 (5), 534540

However, in humans, proline has been known to be catalyzed by proline oxidase (POX), being regulated by age or by the peroxisome proliferator-activated receptor gamma (PPAR) regulator [132,133,134,135]