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Kamath AF, Chauhan AK, Kisucka J, Dole VS, Loscalzo J, Handy DE, Wagner DD (2006) Elevated levels of homocysteine compromise blood-brain barrier integrity in mice

Here, it serves dual functions as both a scaffolding molecule and a kinase

Safety, tolerability, and preliminary activity of CUDC-907, a first-in-class, oral, dual inhibitor of HDAC and PI3K, in patients with relapsed or refractory lymphoma or multiple myeloma: an open-label, dose-escalation, phase 1 trial

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Furthermore, they established that degradation of ETC proteins through hyperactivation of caseinolytic protease P, synergistically enhanced the anti-AML effects of GPX4 inhibition