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In particular, they demonstrate reduced NF-B interaction and decreased transrepression of proinflammatory and apoptotic genes compared to other isoforms ( in vivo studies of GR mRNA/protein isoform overexpression are required to confirm GR isoform-specific functions

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xCT inhibitors can also have therapeutic benefits for ovarian cancer cells growing in a high-glucose tumor environment (e.g., ovarian cancer cells overexpressing SLC7A11, GLUT1, PDK, glutaminase, and GPX)

Bin Li, China, 2008 Introduced MSCs in rodent insomnia models, demonstrating improved sleep cycles via cytokine suppression and GABA receptor upregulation