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The transport capability of MSNs at the sizes of 20, 40, and 80 nm were evaluated by the authors and were calculated to be 44.0%, 59.2%, and 38.6%, respectively, which were all higher than that of free drugs (32.8%), indicating a size-dependent penetration mechanism

As juglone was also inhibiting both ChaC1 and ChaC2 efficiently, it appeared that juglone might be inhibiting ChaC1 at its active site through competitive inhibition with glutathione

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Therefore, genetic depletion of TXN and TXNDR1 with siRNA oligonucleotides disrupts the redox balance mediated by the Trx system in tumor cells, thereby contributing to the inhibition of cell proliferation

Targeting tumour necrosis factor to ameliorate viral pneumonia

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