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these R-loops, in turn, induce replication fork reversal and thereby halt fork progression (Fig

The right choice, however, comes down to one critical factor: absorption

This can occur, for instance, through partial inhibition of replicative DNA polymerases with aphidicolin or under conditions of excessive generation of ROS 14 , which promote dissociation of the fork acceleration factor TIMELESS-TIPIN from the replisome in a manner dependent on the replisome-associated ROS-sensor PRDX2 51