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However, gliomas, characterized as cold tumors, often exhibit poor or non-responsive behavior to ICIs, limiting the success of immunotherapy

10.1093/jxb/44.1.127 J

Upregulation of tight junction protein expression and improvement of junction structure The expression and distribution of tight junction proteins are key factors affecting barrier integrity

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It is widely recognized that oxidative stress and the production of ROS have the potential to hinder mitochondrial activity 110 , leading to the suppression of STAR gene expression