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GSH is synthesized in a two-step reaction catalyzed by -glutamylcysteine synthetase and GSS in the -glutamyl cycle, which includes an additional four enzymes (Figure 1)

Six patients suffered from thalassemia major (TM), four from sickle cell disease (SCD) and two of them from severe congenital neutropenia (SCN)

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Recently, peptides have been applied as ligands to achieve delivery functions in complexes known as peptide-oligonucleotide conjugates (POCs)