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Clinical features of RA primarily include joint swelling, pain, stiffness, weakness, deformity, and fatigue ( Innate immunity plays a critical role in the pathogenesis of RA, including various innate immune cells and components (6)

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CARDIAL-MS (CArdio-Renal-DIAbetes-Liver-Metabolic Syndrome): a new proposition for an integrated multisystem metabolic disease

Consequently, ROS promotes cell growth, proliferation, inflammation, protein synthesis, and gluose metabolism via altering normal gene expressions and thus causes change in DNA structure [52, 53]

By helping to prevent macrocytic anemia, B12 ensures that red blood cells are the correct size and shape to efficiently transport oxygen to starving tissues, alleviating the sensation of air hunger