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The peptide activates AMP-activated protein kinase (AMPK), a central regulator of cellular energy metabolism that promotes fatty acid oxidation while inhibiting lipid synthesis

IGF-1 carries out many of the downstream tissue effects, while the body's feedback loops continue to govern how much GH is released

Storage matters more here than it does for a robust small molecule, because peptides are fragile: heat, light, agitation and freeze-thaw cycles all degrade them, and a degraded peptide simply under-delivers with no visible warning

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Ghrelin is best known as a hunger hormone, but it also stimulates growth hormone release through this separate receptor