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Other studies lead us to suggest an additional possibility, namely, that oxidative stress may result in part from Michael addition of thiols to aminoacrylate generated in the -lyase reaction

In your body, glutathione safeguards cells against oxidative stress and contributes to many other biochemical reactions

Micro RNAs (miRNAs) miR-141, miR-432-3p, miR-200a, have also shown to modulate the activities of KEAP1 and NRF2 in ovarian carcinoma cell lines, breast cancer, esophageal squamous cell carcinoma (ESCC), endometrial cancer tissues, miR-7, directly targeted KEAP1 mRNA in neuroblastoma SH-SY5Y cells, where it activated NRF2-dependent transcription of the antioxidant genes HMOX1 and GCLM [49]

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Author of Outlive and host of The Drive podcast, Attia is a longevity, lifespan, and healthspan truthsayer