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Cellular dynamics following CAR T cell therapy are associated with response and toxicity in relapsed/refractory myeloma

The ability of mitochondria to rapidly adapt to stress, including stress imposed by antimetabolites such as 5FU, means that they have significant potential to dictate therapeutic responses 11

oxidative stress and cellular signalling

Fujishiro, H., Okugaki, S., Yasumitsu, S., Enomoto, S

Glutathione is naturally produced in the liver and plays a key role in neutralizing oxidative stress caused by pollution, UV exposure, and daily metabolic activity

For example, it was said to be 4.6% in the US, 4.7% in Canada, less than 2% in Europe, 0.7% in China and East Africa, and 0.44 to 2.8% in India