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Is it suitable for all age groups

LUNA-18's story began with an almost impossibly large library through mRNA display technology

In a clinical trial, bendamustine, an alkylating agent with purine analog properties, was compared to chlorambucil and achieved better response rates (68 %) with a CR of 31 % and PFS of 21.6 months.42 The CLL10 trial showed that rituximab with a bendamustine dose of 90 mg/m2 in the first-line setting resulted in response rates similar to FCR at 97 %, but with fewer CRs (31 %)

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When talking about its functional duration, it is worth mentioning that even after plasma concentrations decline, hormonal signaling effects may persist

The results were summarised by Cochrane review in 2014