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Animals 11, 2995

Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors

10.3945/ajcn.110.003483 42 ShadelG

Several unanswered questions remain regarding: Long-term receptor adaptation Extended safety observations Pharmacokinetic variability Biological mechanisms Combination pathway interactions These questions are common during the development of novel peptide-based compounds

It was later reported by the researchers that GHK-Cu peptide complex exhibited some potential in increasing the expression of caspase and the associated genes, as well as gene expression associated with DNA repair