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Die-off or Herxheimer reaction is commonly the result of medications such as antifungals or antibiotics

I have been taking tirzepatide for almost a month and am down about 12 pounds

[PubMed: 7148814] 567

Noguchi Y, James J, Fischer J, Hasselgren P (1997) Increased glutamine consumption in small intestine epithelial cells during sepsis in rats

These findings confirm that exposure to both PS and BaP can disrupt metabolic homeostasis in the kidneys, contributing to kidney dysfunction and cell death