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Osterman MT, Rosario M, Lasch K, Barocas M, Wilbur JD, Dirks NL, et al

Current clinical diagnosis primarily relies on proteinuria and glomerular filtration rate indicators, yet their insufficient sensitivity for early renal injury leads to high underdiagnosis rates of nonproteinuric DN

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Tab 2: False positives used to filter the proteomic data (described in Methods)

This additive effect on energy expenditure is why the retatrutide dosage range studied (112mg weekly) produced weight loss outcomes that exceeded all prior incretin-class compounds in head-to-head timelines