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doi: 10.1038/nrendo.2011.174 82 SessaL.MalavoltaE.SoderoG.CipollaC.RiganteD

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GABA is synthesized from the amino acid glutamate with the enzyme glutamate decarboxylase (GAD) and pyridoxal phosphate (which is the activated form of vitamin B6) as the key cofactor