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TB-500's pharmacokinetics reflect its actin-binding behavior

An experimentally defined hypoxia gene signature in glioblastoma and its modulation by metformin

doi: 10.3748/wjg.v21.i14.4310 38 TaioliEFlores-ObandoREAgalliuIBlanchetPBunkerCHFerrellREet al

Research suggests that the T allele is associated is marked reduction in the activity of the GPx1 enzyme, with some studies showing a 40% reduction in GPx1 activity