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This discrepancy primarily stems from methodological variations in patient selection, intervention design, and endpoint assessment, rather than contradicting the established biological plausibility of LC's mechanisms

GABA L-theanine can help stimulate production of the inhibitory, relaxing neurotransmitter called GABA (gamma-aminobutyric acid)

But sometimes, a more-detailed echocardiogram is needed to get a closer look at the mitral valve

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Increased BDI-II scores resulted from items related to mental and physical fatigue (tiredness/fatigue, loss of energy, items referring to cognitive symptoms such as concentration difficulties) apart from one patient, who had a higher score across most items, while still not meeting the criteria for depression