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Another challenge lies in the host specificity of probiotics, where the efficacy of a particular strain in one fish species may not be replicated in others (Lowe et al., 2020)

A controlled trial of 77 overweight or obese people with mood disorders found that combining a low-calorie diet with lion's mane supplementation at three capsules daily for eight weeks resulted in decreased ratings of depression, anxiety and sleep disorders, along with an increase in serum pro-BDNF [1]

This includes medicines bought over the counter at high-street chemists (community pharmacies)