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Analysis of the top 100 differentially expressed genes in tumor cells treated with the combination of nivolumab and ipilimumab showed the enrichment of a myeloid marker, S100A9 , encoding S100 calcium-binding protein A9 (also known as myeloid-related protein 14 or MRP14), as one of the top-scoring hits (Supplementary Fig

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Furthermore, oxidative stress and germ cell toxicity are risk factors for infertility, as is the need to protect germ cells during chemotherapy (Levi et al., 2015