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potentially fatal disturbances of cardiac conduction (widening of QRS), arrhythmias & seizures due to Na channel block (cardiac & CNS) Pharmacokinetics: PO, metabolized in the liver (P450 - 2D6)

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Of mice and men: models and mechanisms of diabetic cardiomyopathy

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191,192 However, in the brain of AD patients, factors such as metal accumulation, overexpression of related enzymes (e.g., NADPH oxidase), and mitochondrial dysfunction are involved in producing excessive ROS, surpassing the ability of the endogenous antioxidant system and resulting in an oxidative imbalance

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