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It also complements clinical observations that thalassemia patients often require folate supplementation to support their high-output erythropoiesis

The effect of impairment in salvage pathway on the NAD + pool might be partially alleviated by compensatory mechanisms affecting 2 other NAD + synthesis pathways, namely the de novo NAD + synthesis pathway and the Preiss-Handler pathway, which, respectively, use circulating tryptophan and nicotinic acid (NA) to produce the NAD + precursor NA mononucleotide (NAMN)

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Inpatient or residential detox is reserved for high-risk cases, like people with seizure history, polydrug use, or unstable health

doi: 10.1016/j.cell.2008.04.052 28 HongCKidaniYA-GonzalezNPhungTItoARongXet al

doi: 10.1371/journal.ppat.1008508 84 VenkatakrishnanASarafianJTJirk-PomajbkovKParkerW