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Hyaluronans also have anti-inflammatory benefits, as well as coating pain receptors, stimulating endogenous synovial fluid production and lubrication effects

NNMT is an enzyme involved in nicotinamide metabolism and energy-related pathways

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In contrast to these TRPM2 inhibitors, an analgesic and antipyretic drug, acetaminophen, was found to activate TRPM2 in rat hepatocytes at high concentrations (1015 M) (Kheradpezhouh et al., 2014)