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Heres a look at the ingredients: Thiamin 25 mg

Effect of Sex There are no differences in the body surface area adjusted unbound clearance between males and females (4.8 0.17 and 4.7 0.07 L/hr per 1.73 m 2, respectively)

Obesity also negatively affects the efficacy of biologic treatment in patients with psoriasis (205)

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The sentence above, which is found in the primary article, would lead you to believe this, but if you dig through the 40-page supplementary information, you unearth this telling table: As you can see, the triglyceride, cholesterol, glucose and insulin levels of mice being fed normal chow are already pretty high (insulin levels at baseline convert to 16.3 microunits/ml)