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Funding: This work was supported, in part, by National Institutes of Health ( grants R01 DK058185, P01 DK068055 (Project 2), P30 DK084567, P30 CA015083, P50 CA127003, as well as by the GIST Cancer Research Fund ( and the Mayo Clinic Center for Individualized Medicine The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Peptides act as signaling molecules supporting the hypothalamus-pituitary-gonadal axis, influencing upstream control of reproductive hormone production

153 (Suppl 1), S191199 (2008)

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One is that GSSG and GS-X produced in cardiomyocytes are pumped out by multidrug resistance protein 1 (MRP1), preventing GSSG or GS-X accumulation in cardiomyocytes [33, 34], and subsequently enter the -glutamyl cycle

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