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Ph/glutathione-responsive release of SO2 induced superoxide radical accumulation for gas therapy of cancer

10.1016/j.molmed.2023.07.002 359 ParkS.-H.LeeJ

Reducing metabolic flux through the SGOC pathway in tumor cells remains a formidable challenge, primarily due to the pathway's inherent redundancy and evolutionarily conserved compensatory mechanisms

T.2010Glutathione S-Transferase P1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinoma.1146 15

however, it was learned during the trial that even in frozen samples reduced glutathione is oxidized over time unless 1.5 M 2-chloro-1-methylpyridinium iodide is added