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Many of them converge on the target of rapamycin (TOR) kinase ( Figure 6A ), a main factor in determining rates of protein turnover and metabolism (Wullschleger et al., 2006)

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Zebrafish macrophages have previously been shown to be required for inflammatory lymphangiogenesis and expression of pro-angiogenic VEGF ligands (83)

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Through physical interaction with the latter, FOXO3 prevents NFkB from undergoing nuclear translocation, and thus attenuates NF-kB-mediated pro-inflammatory response 72

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The potential metabolic benefits of metformin, attributed to its action in the intestine, have also been highlighted

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2010;93(6):379-389.Chan WH, Biswas S, Ashworth JL, Lloyd IC

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Make sure the cap fits well by giving it a light tug

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