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Pure cerebellar ataxia was presented in two cases, while five showed extracerebellar symptoms, including psychiatric symptoms (three case), cognitive dysfunction (two cases), generalized seizures (one case), and retinopathy (one case)

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T cell exhaustion has not been associated with tumoral GPX4 expression, but as our DIO study indicated greater numbers of PD1+/TIM3 + CD8 + T cells in shGPX4 tumors, this finding could be a diet-specific effect

This has led some researchers to hypothesize that TB-500 may increase the growth of new cells and hasten the healing of tissue injuries while improving muscle flexibility