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These results support previous studies in which melatonin, through the activation of the SIRT1 pathway, prevents and protects against neurodegenerative processes, since the benefits include the total preservation of cognitive capacity, protection against amyloid and tau pathology, activation of abnormal protein pathways, and activation of neurotrophy (Sarlak et al., 2013

Subsequently, microglia rapidly engulf the released hemoglobin and metabolize Fe2+/Fe3+ (30)