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1988 Jul;2(3):609-20

& Sears, J

Lupus may also cause narrowing of the blood vessels

This leads to a phenomenon that is referred to as the enhanced permeability and retention effect (EPR) 34,35

These metabolites can cross the BBB, modulate neuroinflammation by inhibiting HDAC activity, and enhance barrier integrity (Berding et al., 2021)

Of note, CD40 is a transmembrane glycoprotein surface receptor, a member of the TNF receptor superfamily, and its activation is associated with increased effectiveness of antigen presentation and the upregulation of major histocompatibility complex class II and costimulatory molecules CD80/CD86