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Among GSH precursors, cysteine availability is typically rate-limiting due to its low intracellular abundance and susceptibility to oxidation

Peptides can also be synthesized in labs

Wynne-EllisMMMursuJJTuomainenTPBertone-JohnsonESalonenJTVirtanenJKet al

CANTATA: Randomized, international, double-blind study of CB-839 plus cabozantinib versus cabozantinib plus placebo in patients with metastatic renal cell carcinoma