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The primers for PCSK6 were designed and purchased from Sangon biotech (Shanghai, China): PCSK6 (forward, 5-ACTCCAGAAGAAGAGGAAGAGTA-3

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In contrast, various natural and synthetic compounds have been reported to shift Hbs allosteric equilibrium towards a high-affinity state and have also been investigated as potential therapeutic agents for the treatment of sickle cell disease

10.1126/science.1241214 Science

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