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IGF-1R and its downstream AKT/mTOR cascade stabilize hedgehog-induced transcription effector Gli2 protein, thereby enhancing a hedgehog-mediated effect on osteoblast differentiation (Shi et al., 2015)

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The multifunctional alarmin HMGB1 with roles in the pathophysiology of sepsis and cancer

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Neuron 105, 776798

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Another natural compound Silibinin also demonstrated potent antiviral effects against chronic hepatitis C [57]

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