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Removal of this loop in class II GRX HsGRX5 had generated an enzyme variant thatin contrast to the wild-typehad detectable reductase activity with roGFP2 (approximately 1.5% of class I HsGRX2) and HED (approximately 0.5% of class I HsGRX2)

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In other words, could exposure of nerve cells to low but above normal concentrations of L-glu (or glutamatergic neurotransmission as a sum of the input via the various molecules involved as discussed above) over an extended period of time also eventually lead to nerve cell death

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2023 Dec Anna Andrea Lauer, Heike Sabine Grimm, Birgit Apel, Nataliya Golobrodska, Lara Kruse, Elina Ratanski, Noemi Schulten, Laura Schwarze, Thomas Slawik, Saskia Sperlich, Antonia Vohla, Marcus Otto Walter Grimm, Ben A Bahr