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Altamura S, Marques O, Colucci S, Mertens C, Alikhanyan K, Muckenthaler MU

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For example, phenobarbital, pregabalin, primidone and topiramate

Importantly, GMP-compliant experimental studies demonstrate that the transition from research-grade to clinical-grade EVs requires substantial process modifications, including controlled cell sourcing, closed-system manufacturing, scalable purification strategies, and validated quality controls (Humbert et al., 2025)