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As described below, ROS may uncouple the eNOS-catalyzed reduction of molecular oxygen from the oxidation of L-arginine, resulting in the paradoxical production of the ROS superoxide anion instead of the reducing NO

Intergenomic distances were subsequently calculated using the Genome BLAST Distance Phylogeny (GBDP) method, applying the coverage algorithm and the recommended distance formula to ensure accurate phylogenetic resolution (Meier-Kolthoff et al., 2013)