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Fermentation of dietary fiber by intestinal bacteria is the major source of short-chain fatty acids, such as butyrate, and various studies have shown that vegetable fibers are helpful at preventing flares of ulcerative colitis (Hanai 2004)

Interleukin-1, on the other hand, enhances the production of nitric oxide in the myocardium, which can have negative inotropic effects, thereby reducing the contractile capacity of the heart 9

*Correspondence: Etheresia Pretorius, [email protected]

AOD-9604 is a synthetic peptide fragment (amino acids 176-191 of human growth hormone) that stimulates fat breakdown through beta-3 adrenergic receptors in adipose tissue, working peripherally on fat cells rather than centrally on hunger signals

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The disease course typically alternates between stable phases and acute exacerbations (AECOPD), with the latter significantly accelerating pulmonary function decline