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The membrane-bound form of TNF- (tmTNF-), signaling primarily via TNF receptor 2 (TNFR2), mediates protective and reparative effects

[PubMed: 8769376] 327

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reviewed that succinic acid facilitates tumor development by providing an energy source and converting tumor-associated M2 macrophages, which suppress the anti-tumor immune response in ovarian cancer (79)

Regarding metabolic inhibitors: HIF-1 inhibitors (e.g., PX-478) can specifically inhibit the enhancement of glycolysis and reduce the release of inflammatory factors (118, 119)