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Indeed, our data also indicated that more pronounced metabolic changes at the gut level are contributing to the anti-obesity effect compared to metabolic regulations at the liver level

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For example, studies performed in murine J774A.1 macrophages showed that TMAO induced stress and led to increased protein expression of GRP94 and HSP70, which may participate in the abnormal activation of macrophages involved in foam cell formation (Mohammadi et al., 2018)