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5 With the pharmacokinetic and adverse-effect profiles of various analgesic medications in mind, practitioners should consider the recommendations summarized in TABLE 1 to achieve safe and adequate pain control in cirrhotic patients

Li JQ, Song P, Jiang TT, Dai DJ, Wang HY, Sun J, et al

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The substrates and products of the DHODH reaction have opposite effects on ferroptosis, suggesting that the potential role of DHODH in regulating ferroptosis sensitivity is independent of its function of producing pyrimidine nucleotides

In contrast, hemolysis occurring with the G6PD Mediterranean variant is more severe because a larger population of circulating erythrocytes is vulnerable to injury