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7 The Genetics of Homocycsteine Metabolism Genetic variation (polymorphism) fundamentally impacts the activities of enzymes involved in homocysteine metabolism

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Chang L.Y., Slot J.W., Geuze H.J

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To differentiate between the potential involvement of these two consequences in H 2 O 2 -induced sensitization to TNF hepatotoxicity, we first exposed HepG2 cells to (BSO), a potent inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in the glutathione synthesis pathway (Fig