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Therefore, more effective interventions to prevent the development of DKD are urgently needed

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doi: 10.1038/nrd3793

Studies combining animal models and patient-derived data have unequivocally established that dysregulated NIK activity acts as a pathogenic driver in a spectrum of human diseases, including immunodeficiencies, autoimmune disorders, and multiple cancers

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Evidence indicates that an altered BBB contributes to iron accumulation, particularly in substantia nigra and striatum, and neuroinflammation in PD models