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AS patients considering tirzepatide should be aware that spinal and joint pain changes during treatment may reflect either disease activity changes or the normal musculoskeletal adaptations to significant weight loss

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Thus, the present invention pertains, in part, to methods of modulating the copy number, amount, and/or activity of one or more biomarkers described herein (e.g., targets listed in table 1, table 2, examples, etc.) and the use of the biomarkers and/or modulators for therapeutic, diagnostic, prognostic, and screening purposes, as further described below