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Mechanisms of in vitro resistance to dihydroartemisinin in Plasmodium falciparum

Patient selection and subgroup analyses Participation in this nested substudy of SUSTAIN CSX was optional for the sites and within the framework of the existing ethical approval [14]

Gao, H., Liu, C., Song, S

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To clarify how integrated safety data operates in practice, the following areas are addressed: Clinical safety monitoring during development Pharmacovigilance Adverse Event Assessment Post-approval safety oversight and signal detection Regulatory documentation and data traceability Clinical Safety Monitoring During Drug Development Clinical teams monitor safety data continuously during trials to detect emerging risks early

These are really reactive & lead to the production of hydrogen peroxide (HO) which is one of those ROS that glutathione is needed to neutralize